9 months agoEverton take Idrissa Gueye off market

first_imgEverton take Idrissa Gueye off marketby Paul Vegas9 months agoSend to a friendShare the loveEverton have taken Idrissa Gueye off the market.A target for PSG, it had been claimed Everton would be willing to sell the midfielder for a set price of €45m.However, Foot Mercato says Everton have informed the player’s agent that Gueye is not for sale this month.Indeed, it’s been revealed Everton and PSG have broken off negotiations for the past week. TagsTransfersAbout the authorPaul VegasShare the loveHave your saylast_img read more

22 days agoCrouch questions Liverpool nerves after RB Salzburg win

first_imgCrouch questions Liverpool nerves after RB Salzburg winby Ansser Sadiq22 days agoSend to a friendShare the lovePeter Crouch has questioned Liverpool’s nerves after Wednesday’s 4-3 win over RB Salzburg in the Champions League.The European champions blew a three-goal lead at Anfield when Erling Braud Haaland equalised for the visitors.And Crouch says the performance was “absolutely mental” from his former side.”It was mental, absolutely mental,” Crouch said on BT Sport.”Liverpool were flying, playing some of the best attacking football I have seen from them this season. And then the second half, I don’t even know where to begin. 3-3, I just couldn’t have seen it, and then Salah pops up with the winner.”An incredible match, highly entertaining, but for the wrong reasons for Liverpool in the end. They got a bit nervy Liverpool, you have to say.”Once the first goal went in, then the second, Fabinho, whose normally so calm on the ball, was passing it out of play, they weren’t as intricate as they were in the first half.”So it definitely affected them but the fourth goal killed them off and then they controlled the game and managed it out.” About the authorAnsser SadiqShare the loveHave your saylast_img read more

Just in Time for Foster Youth to hold college bound celebration

first_img KUSI Newsroom, 00:00 00:00 spaceplay / pause qunload | stop ffullscreenshift + ←→slower / faster ↑↓volume mmute ←→seek  . seek to previous 12… 6 seek to 10%, 20% … 60% XColor SettingsAaAaAaAaTextBackgroundOpacity SettingsTextOpaqueSemi-TransparentBackgroundSemi-TransparentOpaqueTransparentFont SettingsSize||TypeSerif MonospaceSerifSans Serif MonospaceSans SerifCasualCursiveSmallCapsResetSave SettingsSAN DIEGO (KUSI) – Dozens of foster youth who’ve beat the odds to head for college will start their journey with help from Just in Time for Foster Youth (JIT) through its College Bound service.College Bound provides young people with everything they need to succeed in higher education, including school supplies, electronics, household items and a community with ongoing support.JIT will host the College Bound kick-off “pep rally” at the San Diego Central Library on Saturday, June 15, 2019, with the College Bound Awards following on Saturday, June 29, 2019.To learn more about College Bound, volunteer opportunities or how to invest, please visit www.jitfosteryouth.org Posted: June 14, 2019 June 14, 2019 KUSI Newsroom Just in Time for Foster Youth to hold college bound celebration Categories: Good Morning San Diego, Local San Diego News FacebookTwitterlast_img read more

Apple slices HomePod price to 299

first_img Comments Best Buy reading • Apple slices HomePod price to $299 News • Get a refurbished Apple HomePod for $194 Tags See It Aug 31 • iPhone 11, Apple Watch 5 and more: The final rumors $299 Mentioned Above Apple HomePod (White) 3 Review • Apple HomePod review: Great sound, but it’s trapped in Apple’s world Smart Speakers & Displays Clarification at 8:30 a.m. PT: The HomePod was launched in February 2018. See It Apple started selling its Siri-powered HomePod speaker in February 2018 to compete with Amazon’s Alexa-enabled Echo devices and the Google Assistant-powered Google Home. However, Apple has struggled to catch up with its rivals, which both offer $50 version of their speakers. As of December, only 6% of smart speaker users in the US had a HomePod, according to a report from Consumer Intelligence Research Partners, out of 66 million smart speakers.HomePod prices have dropped before. During the Black Friday sales season, the speaker was available for $250 and we’ve seen that deal pop back up occasionally. See it 1:00 29 Photos Apple Apple’s HomePod now costs a little less. Tyler Lizenby/CNET Apple cut the price of its HomePod speaker by $50 on Thursday. Both the white and space gray versions of the speaker, which previously cost $349, are listed for $299. Apple wasn’t immediately available to comment on whether this is a permanent drop.Read more: Will HomeKit and HomePod get any attention at WWDC?The HomePod was immediately available at the newly discounted price at Apple.com. Some other retailers, such as Walmart, had yet to reflect the new price on the first day. (Note that CNET may get a share of revenue from the sale of products linked from this page.) See HomePod at Apple Preview • Hey Siri, beat Amazon, Google and Sonos: Apple HomePod hits Feb. 9 Share your voice Apple • Adorama Now playing: Watch this: Aug 31 • iPhone XR vs. iPhone 8 Plus: Which iPhone should you buy? Aug 31 • Best places to sell your used electronics in 2019 See All $299 Apple HomePod $299 $299 CNET may get a commission from retail offers. Unboxing the new Apple HomePod See It Aug 31 • Your phone screen is gross. Here’s how to clean it HomePod gets calling update Google Applelast_img read more

Ancient bacterial mats may have been key to first mobile animals

first_img The mats, which the researchers believe are likely similar to the type that evolved in some early lagoons during the Ediacaran Period, some 542 million years ago (the time most agree multicellular animals first began to appear) are comprised of a bottom layer of sulphide-oxidizing bacteria, which is covered by a top layer of blue green algae, which produces the oxygen through photosynthesis. They found oxygen levels of between 0.25 and 0.45 atm near the mats, compared to 0.10 at or near the surface.The findings are important because fossil evidence suggests mobile animals first evolved in early salty lagoons that should have been too salty to produce normal plant growth.Of course there is one hiccup in the theory, and that is the fact that the mats only produce oxygen during the day when the sun is shining; oxygen levels around the mats plunge at night, leaving the lagoons a very inhospitable place. However, at Los Roques, there are some insect larvae that exist inside the mats that for the most part shut down at night; hibernating, if you will, and thus can survive with almost no oxygen when it’s dark. Gingras and his team support the notion that perhaps some early life forms could have done the same, though others are not quite ready to jump on that bandwagon.Another issue is that the results are based on the notion that the mats that exist today are in fact the same as the mats that existed way back then; a bit of a leap seeing as how there is really no evidence to support such a supposition. Thus, in order for the ideas suggested in this paper to gain credence, evidence of some similarity will have to be found through further research. © 2010 PhysOrg.com This document is subject to copyright. Apart from any fair dealing for the purpose of private study or research, no part may be reproduced without the written permission. The content is provided for information purposes only. Citation: Ancient bacterial mats may have been key to first mobile animals (2011, May 16) retrieved 18 August 2019 from https://phys.org/news/2011-05-ancient-bacterial-mats-key-mobile.html More information: Possible evolution of mobile animals in association with microbial mats, Nature Geoscience (2011) doi:10.1038/ngeo1142AbstractComplex animals first evolved during the Ediacaran period, between 635 and 542 million years ago, when the oceans were just becoming fully oxygenated. In situ fossils of the mobile forms of these animals are associated with microbial sedimentary structures1, 2, 3, and the animal’s trace fossils generally were formed parallel to the surface of the seabed, at or below the sediment–water interface4, 5. This evidence suggests the earliest mobile animals inhabited settings with high microbial populations, and may have mined microbially bound sediments for food resources6, 7, 8. Here we report the association of mobile animals—insect larvae, oligochaetes and burrowing shore crabs—with microbial mats in a modern hypersaline lagoon in Venezuela. The lagoon is characterized by low concentrations of dissolved O2 and pervasive biomats dominated by oxygen-producing cyanobacteria, both analogous to conditions during the Ediacaran. We find that, during the day, O2 levels in the biomats are four times higher than in the overlying water column. We therefore conclude that the animals harvest both food and O2 from the biomats. In doing so, the animals produce horizontal burrows similar to those found in Ediacaran-aged rocks. We suggest that early mobile animals may have evolved in similar environments during the Ediacaran, effectively exploiting oases rich in O2 that formed within low oxygen settings. Explore further Modern animal-biomat associations from Los Roques. b, Potential Upper Ediacaran and Lower Cambrian associations. Image illustration: Nature Geoscience, doi:10.1038/ngeo1142 (PhysOrg.com) — Researchers from Canada studying the highly salty coastal lagoons at Los Roques, Venezuela and the microbial mats found at the bottom of the sea there, have discovered that oxygen levels in the mats, at least in the day time, are high enough to support the development of mobile life forms. Led by University of Alberta palaeontologist, Murray Gingras, the team writes in Nature Geoscience, that levels of oxygen on the ocean floor were up to four times as high as that near the surface; high enough to support the development of mobile sea life; which the team believes could explain how early life forms could have evolved in waters with high salt concentrations. How plants drove animals to the landlast_img read more

The language of music

first_imgAgainst the backdrop of rapid urbanization and growing metro culture which has created vulnerability of the traditional artistes, the project presents a compelling vision for indigenous design, the redesign of new economies centred on innovation, well being and compassion. The project emphasise values like, How the wisdom of the past can be made accessible to people.The project presents both traditional and new instruments based on Indian sitar, Burmese saung harp, Thai xylophone, Korean kayagum, Chinese guzheng and pipa, Vietnamese dan tranh, Javanese and Balinese gamelan, chanting and others. New instruments with embedded computation demonstrate interactions through gesture, touch, pull, movement, gaze and kinesthetic action. In addition, through responsive computing, people by their position, gesture, and movements control musical events in the exhibition environment.The museum landscapes exhibition builds on a series multimedia museum works, showing intersections between traditional and modern art, design and technology, such that the results help both traditional and modern societies. The works show that the wisdom of traditional communities can positively negate the homogenising aesthetics of modern media technology.When: On till 16 January 2014Where: National Museumlast_img read more

TMC heavyweights go on campaign trail across state

first_imgKolkata: Trinamool Congress candidates across the state hit the campaign trail on Sunday, with party leaders Subrata Mukherjee, Kakoli Ghosh Dastidar, Mala Roy, Mamata Bala Thakur and Moon Moon Sen among others seen interacting with voters of their respective constituencies.Mala Roy, who is contesting from the Kolkata South seat, started her campaign near the Tollygunge railway station, accompanied by state Public Works Department (PWD) minister and Tollygunge MLA Aroop Biswas. Roy braved the scorching summer heat and walked across ward 81 of Kolkata Municipal Corporation (KMC), interacting with the people. She gave a patient hearing to problems in her constituency, including those of the slum dwellers and assured them that she would address the issues, if she is elected. Also Read – Bose & Gandhi: More similar than apart, says Sugata Bose”Our party supremo has given the call for the party to win all 42 Lok Sabha seats in Bengal. We are her soldiers and will try our best to fulfill her dream,” Biswas said. Meanwhile, senior TMC leader Sobhandeb Chattopadhyay was found making wall graffiti in favour of Roy and also painting the symbol of the party on a wall. TMC candidate from Bankura and senior party leader Subrata Roy walked and also boarded a toto during his campaign. “I have an emotional attachment with the people of Bankura and my work particularly for the Public Health & Engineering department, has brought about a major boost to water supply in this district. I will urge those who have benefitted from my work to vote for me,” Mukherjee said. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataMukherjee had lost ten years ago when he had contested in Bankura on a Congress ticket. Kakoli Ghosh Dastidar, TMC candidate from the Barasat seat, attended a programme of the Matua community at Akarampur in Habra on Sunday. She also danced to the tunes of a devotional song of the community. The votes from the Matua community, which accounts for around 10 percent of the total votes, are going to be a factor in the Barasat seat. Trinamool Congress candidate from Bongaon Mamata Bala Thakur offered her prayers at Jaleshwar Temple in Gaighata and also went to a nearby mosque to seek blessings from the head of the mosque. She then walked in and around the Jaleshwar area, seeking votes. Trinamool Congress candidate from Asansol Moon Moon Sen campaigned at Amritnagar in Ranigunj. Addressing a public gathering, she said that some Opposition parties may come and offer money, seeking votes. “If they offer money, you take it but you should vote for Didi (Mamata Banerjee),” she maintained.last_img read more

EC issues showcause notice to BJP TMC leaders

first_imgKolkata: The Election Commission has served a show-cause notice each to the BJP district president of Nadia Mahadev Sarkar and Trinamool Congress MLA from Chakdah Ratna Ghosh Kar, for their derogatory remarks. Sarkar had made some derogatory remarks on Mahua Moitra, who is contesting the ongoing Lok Sabha elections on a Trinamool Congress ticket. The Commission has taken a strong objection to his remarks after watching the video where he was heard saying the words. Sarkar has been asked to clarify why he made such remarks about a candidate of his rival party. Also Read – Rs 13,000 crore investment to provide 2 lakh jobs: MamataThe Commission had earlier sought a report from the District Magistrate of Nadia on April 17, regarding the statements made by Ghosh Kar. The Commission has now show-caused her after it found her statements highly derogatory in nature. The office of the Chief Electoral Officer (CEO) has gone through the report submitted by the DM in this regard. The TMC MLA found herself at the centre of controversy after she made some objectionable remarks regarding the Central Force. It was alleged that during a closed door party meeting, she had appealed to the members of the party’s Mahila Morcha to “chase Central Forces away with broomsticks.” In another development, an FIR was lodged with the Hooghly police against Locket Chatterjee, who is contesting the election from Hooghly Lok Sabha constituency on BJP’s ticket. During a rally, Chatterjee had allegedly made some remarks which could have triggered communal tension in the area.last_img read more

Arcadios World

first_imgFacebook Comments Related posts:Arcadio’s World Arcadio’s World Arcadio’s World Arcadio’s Worldlast_img

Etihad investment deal allows AlItalia to spread its wings again

first_imgEtihad Airways and Italy’s national carrier AlItalia have signed a €1,758 million transaction implementation agreement designed to recapitalise the Italian carrier and set up Etihad further in the European market.The deal will see Etihad become a minority stakeholder at 49 per cent in the airline with an equity injection of €560 million with a further contribution of €300 million to come from existing AlItalia shareholders.Financial institutions and existing bank shareholders have also provided €598 million in short and medium term debt and €300 million of new loan facilities have also been extended by Italian financial institutions.This financial restructuring remains conditional on the achievement of certain benchmarks by AlItalia and regulatory approval by Italian authorities.Etihad Airways president and chief executive officer James Hogan said that Etihad made a strategic investment in AlItalia because it believes the airline has growth potential.“With the right level of capitalisation and a strong, strategic business plan, we have confidence the airline can be turned around and repositioned as a premium global airline once again,” Mr Hogan said.“Alitalia is the perfect ambassador for Italy and all that it represents,“As we revitalise the brand, the airline will increasingly embody all that we recognise as quintessentially Italian – the history, culture, food and fashion. It must be an airline of which Italians can be proud,“However ultimately it has to work as a business and the goal is for sustainable profitability from 2017.”The new business plan for AlItalia focuses the airline on long haul flights from Rome and Milan international airports and increased connectivity between Italy and the UAE including between Venice, Catania and Bologna and Abu Dhabi.Five new routes to Rome will be launched over the next five years while long haul flights to Milan will double to 25 by 2018.Source = ETB News: Tom Nealelast_img read more

Recommended Links

first_img Recommended Links — Editor’s note: Yesterday, Doug Casey shared his views on the self-identified “elite.” If you missed it, you can read it right here. Today, Doug breaks down the growing migrant crisis. Doug says this crisis will be “one of the biggest problems in the next generation”…and below, he discusses how it can be solved. [This essay was originally published in the October issue of The Casey Report.] Let me start by saying I’m all for immigration and completely open borders to enable opportunity seekers from anyplace to move anyplace else. With two big, critically important, caveats: 1) there can be no welfare or free government services, so everyone has to pay his own way, and no freeloaders are attracted 2) all property is privately owned, to minimize the possibility of squatter camps full of beggars. In the absence of welfare benefits, immigrants are usually the best of people because you get mobile, aggressive, and opportunity-seeking people that want to leave stagnant and repressive cultures for vibrant and liberal ones. That was the case with the millions of immigrants who came to the US in the late 19th and early 20th centuries. And they had zero in the way of state support. But what is going on in Europe today is entirely different. The migrants coming to Europe aren’t being attracted by opportunity in the new land so much as the welfare benefits and the soft life. Western Europe is a massive welfare state that is providing free food, housing, medical care, schooling, and living expenses to all comers. Benefits like these will naturally draw in poor people from poor countries. For the most part they’ll be unskilled, poorly educated, and many will have a bad attitude. The question arises why—since they’re almost all Muslims—they aren’t being welcomed by Saudi Arabia, the UAE, Qatar, or Brunei, which are wealthy Muslim countries. What we’re talking about here is the migration of millions of people of different language, different race, different religion, different culture, and different mode of living. If you’re an alien and you’re 1 out of 10,000, or 1000, or even 100, you’re a curiosity, an interesting outsider. And you’d have to integrate in the new society. But an influx of millions of migrants can only destroy the old culture. And guarantee antagonism—especially when the locals are forced to pay for it. In many ways, what’s happening now isn’t just comparable to what happened 2,000 years ago with the migration of the Germanic barbarians into the Roman Empire. It’s potentially much more serious. Although most of the migration will be out of Africa, it’s supposed to be official Chinese policy to migrate about 300 million Chinese into Africa in the years to come. They’re employed in building roads, mines, railroads and other infrastructure. The Africans like the goodies, but don’t like the Chinese. It has the makings of a race war a generation or so in the future. The problem won’t only be tens or hundreds of millions of Africans migrating to Europe, but tens or hundreds of millions of Chinese migrating to Africa. The EU is a huge aggravating factor with the migrant situation. Brussels is full of globalists and doctrinaire socialists who not only promote bad policies, but make the whole continent pay for the mistakes of its most misguided members. The migrants, who are manifestly unwelcome in Hungary, Poland, and other Eastern European countries, will prove another big impetus for the breakup of the EU. Millions of Africans will want to emigrate, especially to the homelands of their ex-colonial masters in Europe. The colonizers are now themselves being colonized. Fair enough, I suppose; a case of the sins of the father truly devolving upon the sons. If I was an African from south of the Sahara, I’d absolutely try to get to Italy or Greece or France or Spain or on my way to Northern Europe to cash in on the largesse of these stupid Europeans. – This is a different kind of bubble. This bubble was inflated because interest rates were held too low for too long. It’s global in scope. And it’s in a market that’s much larger than the stock market, but not nearly as well understood. See our full analysis right here. The Best Place to Hide Your Money It’s tax-free. Pays up to 37 times more than bank accounts. And you DON’T NEED TO REPORT IT TO THE IRS. No wonder the government doesn’t want you to know about this secret account. Click here. I’m a fan of what’s left of Western Civilization. I hate to see it washed away. But that’s what will happen if the floodgate is opened. Unless the Europeans get in front of this situation, it’s not just some refugees from the Near East they’ll have to deal with. Especially with the economic chaos of The Greater Depression, it’s going to be many millions from Africa, and then perhaps millions more from Central Asia, and even India and Bangladesh. The world is becoming a very small place. What happens when scores of thousands of migrants set up a squatter camp someplace—with no food, shelter, or sanitary facilities? What will happen when there are scores or hundreds of squatter camps? Unlike the Goths and the Vandals, who became the new aristocracy, the chances of the Africans integrating is essentially zero. The situation is likely to be most stressful… Some will say “But you have to be charitable, you can’t just let them starve because they’ve had some bad luck”. To that I’d say an individual, or a family, can have some bad luck. But the places these people come from have had “bad luck” for centuries. Their bad luck is the consequence of their political, economic, and social systems. Their cultures—let me note the elephant in the room—are backward, degraded, and unproductive. It makes no sense, it’s idiotic, to import—at huge expense—masses of people that have a culture of “bad luck”. On just one day recently, the Italian Coast Guard rescued 10,000 Africans off the Libyan coast—almost all men from Guinea, Gambia, Nigeria, and neighboring countries—and transported them to Italy. It’s hard to see them ever going back home. But it’s certain they’ll encourage their friends and families to join them. The situation can only get worse. Why? In 1950, the 250 million Africans were only 9% of the world’s population; it’s 27% now, but there will be 4 billion, for 40%, in 2100. Making that observation is highly politically incorrect, and presumably racist. I’ll have more to say on racism in the future. But the fact is that Africa has always been an economic basket case; if Vasco Da Gama had thrown out a wheel when he was rounding the Cape, he would also have had to throw out an instruction book on how to use it. But nobody could have read it. Be that as it may. But Europeans made things worse when they conquered the continent and divided it up into political entities that made zero sense from a cultural, linguistic, religious or tribal viewpoint. That guaranteed chaos for the indefinite future. That’s why it’s always a mad scramble to get control of the government in these countries, in order to loot the treasury, entrench one’s cronies, and punish one’s enemies. Until there’s a bloody revolution, and the shoe goes on another foot. Here’s the takeaway. The population of Africa is going up by several billion people in the years to come. The net wealth of the continent is going nowhere. The locals will want to move wholesale to Europe, where the living is easy. And where the politically correct Cultural Marxists are anxious to destroy their own civilization. Meanwhile, there are hundreds of think tanks in the U.S. alone, most located within the Washington Beltway who believe that these people should be encouraged to migrate, or imported en masse. They’re populated by partisan academics, ex-politicos, retired generals and others circulating through the revolving doors of the military/industrial/political/academic complex. They’re really just propaganda outlets, funded by foundations, and donors who want to give an intellectual patina to their views and, to use a popular phrase, “make a difference”. Think tanks, and their cousins, the lobbyists and the NGOs, are mostly what I like to call Running Dogs, who act as a support system for the Top Dogs in the Deep State. Their product is “policy recommendations,” which influence how much tax you have to pay and how many new regulations you have to obey. Think tanks are populated almost exclusively by people who are, simultaneously, both “useful idiots” and “useless mouths.” They’re no friends of the common man. The migration policies they’re promoting are creating minor chaos now. With world-class chaos in the wings. Let me repeat, and re-emphasize, what I said earlier. The free-market solution to the migrant situation is quite simple. If all the property of a country is privately owned, anyone can come and stay as long as he can pay for his accommodations. When even the streets and parks are privately owned, trespassers, beggars, squatters, migrants, vagrants and the like have a problem. A country with 100% private property, and zero welfare, would only attract people who like those conditions. And they’d undoubtedly be welcome as individuals. But “migration” would be impossible. This is how the migration problem could be solved. You don’t need the government. You don’t need the army. You don’t need visas or quotas. You don’t need laws. You don’t need treaties to solve the migration problem. All you need is privately owned property and the lack of welfare benefits. Instead, think tanks will come up with some cockamamie political solution. But the good news is that it will speed up the disintegration of the EU. My prediction that the Continent will one day just be a giant petting zoo for the Chinese is intact—assuming the current wave of migrants approve. There will also be an exodus of capital and people from Europe to parts of Latin America, plus to the U.S., Canada, Australia, and New Zealand. This is, obviously, bad for Europe and good for the recipient countries, since these emigrants will be educated and affluent. Editor’s note: If you haven’t seen it, Doug has just released his latest and most controversial prediction yet. It involves a shocking currency ban (not gold) that may soon take effect under the Trump presidency. Already, Fed members have met in private to discuss this matter. And the savings of millions could be devalued if this goes into effect. To watch the interview and discover the four steps Doug is taking to prepare, click here.last_img read more

Recommended Link

first_imgRecommended Link At 28, he made partner at global financial powerhouse Cantor Fitzgerald.By 30, he was routinely trading $1 billion — per minute.And by 38, he helped his firm build Wall Street’s fastest high-speed trading system.His name is Jason Bodner and he was so influential on Wall Street… President Clinton visited his trading floor. So did President Bush. Bloomberg (the $10 billion financial giant) asked to partner with Jason. Now you can see how his breakthrough system can spot America’s fastest-growing stocks up to 30 days in advance. — — • After all, Gates is the world’s second-wealthiest man… He’s worth nearly $100 billion.He’s also one of the world’s most outspoken environmentalists. Last year, he helped launch the Global Commission on Adaptation, a commission focused on climate adaptation solutions.Because of this, Gates’ opinion carries tremendous weight. It can both shape public opinion and guide policy at the highest levels of government.I bring this up for a simple reason.• Climate change is one of today’s hottest political issues…Just look at how much attention the Green New Deal (GND) received. It’s all many politicians want to talk about.Interestingly, the version of the GND that went before the Senate last month barely mentioned nuclear power… despite being one of the cleanest, cheapest, and most dependable forms of mass energy.Of course, that version was steamrolled on the Senate floor… but as I explained Tuesday, concern over climate change isn’t going anywhere. And I believe we’ll see another version of the GND… one that doesn’t have nuclear power as a footnote, but rather as a focal point.If that happens, uranium – the feedstock of nuclear power plants – should explode in value. Not only that, stocks leveraged to uranium could easily deliver returns in excess of 1,000%.I’ll show you why in a second… and how to position yourself for this opportunity. But you should know something first…• I’m not the only Casey Research analyst excited by what Gates said…According to our in-house commodities expert Dave Forest, Gates’ comments reflect a major change in perception toward nuclear power.And Dave knows what he’s talking about.He’s a true industry insider. He spent the last two decades of his career searching for new discoveries and breakthroughs in the resource space. He also founded his own mineral exploration and development companies.And he believes the nuclear industry has reached an “inflection point,” saying:Gates is quite correct that nuclear power is the world’s only non-carbon source of baseload power. It’s why Patrick Moore, an early member of Greenpeace, has been pro-nuclear for decades.But despite obvious benefits, nuclear power has stalled since its initial buildout during the late 1960s and 1970s.So, the recent groundswell of nuclear support is interesting. Perhaps Fukushima demonstrated for people like Bill Gates that even a worst-case scenario isn’t that bad – especially weighed against the perceived threat of climate change and the real threat of massive pollution from coal.Whatever the case, public opinion is a powerful factor in driving policy. And it looks like the world is going to push its leaders to re-embrace nuclear as a climate solution.In short, we’ve seen a complete 180 in public perception of nuclear power recently.That alone should get you excited about uranium. But it’s not the only reason to be bullish. Wall Street Will NOT Want You to Uncover This Man’s Identity… Get all the details here He’s revealing secrets he learned while working in the live trading pit of the Chicago Board Options Exchange… And giving you the opportunity to get a DOUBLE-YOUR-MONEY trade recommendation in real time… All you need to do is get “in the room”… It’s as close as you possibly can get to trading right alongside a real market wizard. Recommended Link • Industry fundamentals are rapidly improving…In fact, Dave says an even bigger announcement was made just one week after NELA was introduced:On April 1, reports emerged that China is about to approve construction of new reactors. Papers quoted the head of China’s National Nuclear Safety Administration, Liu Hua, saying definitively: “China will start building new nuclear projects this year.”This would be the first approval of new reactors in China in three years – and Liu’s comments suggest building is going to restart imminently.This is hugely bullish for uranium producers. More from Dave:China is the biggest driver of global reactor buildouts this decade.Chinese-installed nuclear capacity has increased more than 20-fold since 1990.China’s reactor builds are the biggest factor affecting global uranium demand. Even with the slowdown in reactor construction recently, Chinese projects still account for 25% of the nuclear capacity being built worldwide.But here’s the thing.• China isn’t winding down nuclear reactor construction anymore… It’s ramping up. Dave explains:China has lots of nuclear projects it could choose to activate. Planned and proposed projects across the country would add 162,476 megawatts electric of capacity. That would triple China’s overall nuclear generation.And several recent moves from China’s uranium companies support a coming surge.• This is all great news for speculators… Public perception towards nuclear power has suddenly turned positive. At the same time, uranium demand is set to soar.This is a recipe for much higher prices.Remember, uranium stocks are some of the most explosive on the planet – when they move, they really move.For instance, Paladin Energy – a small uranium stock – went from one cent in 2003 to eight dollars in 2007… a 95,600% gain in less than four years.That’s a life-changing return.But even blue-chip uranium stocks delivered monster returns during the last bull market. Take Cameco – the world’s largest publicly traded uranium company. It surged more than 3,395% from 2000 to 2007.• And the next uranium bull market could hand us even bigger gains… I say this because the sector’s been absolutely decimated.According to Forbes, there were 450-plus companies in the uranium space prior to Fukushima. And the market capitalization of publicly traded uranium stocks was approximately $130 billion.Today, there are about 40 uranium companies worldwide… with a combined market value of only about $10 billion.In other words, it wouldn’t take much money to move the uranium market.So consider speculating on uranium stocks if you haven’t yet.But remember, uranium stocks can be incredibly volatile. Never bet more money than you can afford to lose. Position-size appropriately. Do your research and take profits as they come. It only takes a small amount to capitalize on the next bull market.Regards,Justin Spittler Salento, Colombia April 25, 2019P.S. International Speculator editor Dave Forest is one of the most well-connected, experienced resource speculators on the planet. He’s a true industry insider with 20-plus years’ experience in this space… and has built his readers a portfolio to profit from the coming bull market in uranium.But there’s another story he recently unveiled that no one else is talking about today…Dave says a radical new technology is about to take down the world’s leader of electric vehicles… and send a specific metal soaring in the process. Not only that, it will flood one tiny, specific stock with a massive windfall starting any day now. Go here to get all the details.Reader MailbagDo you believe a “nuclear renaissance” is underway? If so, are you positioned to profit? Let us know at feedback@caseyresearch.com.A Second Chance to Profit From Wall Street Insider’s Breakthrough SystemLast night, Casey Research friend and Wall Street insider Jason Bodner revealed the secrets behind his revolutionary trading system… a system that consistently spots the market’s fastest-growing stocks up to 30 days in advance.If you missed it, you’re in luck.You still have the chance to claim Jason’s No. 1 recommendation. The potential returns could be enormous – as much as $9,385 in one trading day. So for a limited time, you can learn how to profit from his system by going right here to watch the replay of the event… By Justin Spittler, editor, Casey Daily DispatchBill Gates is all in on nuclear power.Just look at what he told his 47 million Twitter followers on March 28.If you read Tuesday’s Dispatch, you know the Nuclear Energy Leadership Act (NELA) is a big deal.It aims to “reestablish U.S. leadership in nuclear energy” and reduce carbon emissions. It also, as Gates noted, would accelerate development of advanced nuclear reactor technologies.But that’s not all that Gates said about this historic piece of legislation…That’s right. Gates believes nuclear power should play a major role in combating climate change.Not only that, he likes nuclear power for the same reasons we at Casey Research do.In short, Gates doesn’t think we can have a green economy without nuclear power.It’s also worth mentioning that Gates is the Chairman of the Board for TerraPower, a leading nuclear innovation company.That’s huge. You can still learn to trade from a true Wall Street legend Watch the video herelast_img read more

When Medicare in 2011 agreed to pay for a procedur

first_imgWhen Medicare in 2011 agreed to pay for a procedure to replace leaky heart valves by snaking a replacement through blood vessels, the goal was to offer relief to the tens of thousands of patients too frail to endure open-heart surgery, the gold standard.To help ensure good results, federal officials limited Medicare payment only to hospitals that serve large numbers of cardiac patients.The strategy worked. In the past seven years, more than 135,000 mostly elderly patients have undergone transcatheter aortic valve replacement, known as TAVR. And TAVR’s in-hospital mortality rate has dropped by two-thirds, to 1.5 percent.Now, in a campaign motivated by a muddy mix of health care and business, smaller hospitals and the medical device industry are arguing that the technique should be more widely deployed. They note only about half of the nearly 1,100 hospitals offering surgical valve replacement can do TAVR. And they say current limitations discriminate against minorities and people in rural areas, forcing patients to undergo a riskier and significantly more invasive treatment — or miss getting a new valve altogether. Hospitals that already have a TAVR franchise are fighting to stifle new competitors, saying programs that don’t do enough procedures would not provide high-quality care.At stake is the care of thousands of patients. Half of the more than 250,000 Americans estimated each year to develop severe aortic valve stenosis — narrowing of the valve that regulates the flow of blood from the heart to the largest artery of the body. Getting an artificial heart valve lowers that death rate to as low as 17 percent over two years, studies show. Also at stake is the $45,000 Medicare pays hospitals for each TAVR case — excluding the doctor’s fee. While hospitals typically make only a small profit on the procedure — partly because the device costs more than $30,000 — they benefit because each TAVR patient typically needs other cardiac services and tests that can boost the hospital’s bottom line. In addition, offering TAVR carries a cachet that helps recruit and retain top specialists, who bring in more patients.At a Medicare advisory committee hearing in Baltimore on July 25, both sides of the debate emphasized how they were seeking to help patients. But the economics of TAVR was ever-present given the horde of medical device and hospital officials and industry analysts in the audience. The committee split on the issue, although a majority of members backed the continued use of volume requirements. The Centers for Medicare & Medicaid Services is expected to decide later this year whether to change its patient volume minimum for TAVR.Dr. Jason Felger, a heart surgeon who wants his community hospital in San Angelo, Texas, to offer the procedure, said behind the fight over TAVR is protecting profit and revenue. He refers patients to hospitals more than three hours away for the procedure or, if they aren’t willing to travel, they risk their lives to undergo the conventional operation. Hospitals that offer TAVR, he said, aren’t willing to give up the referrals they now rely on from other hospitals. “It’s all about the money,” he said.Improving a hospital’s reputationUnlike open-heart surgery, in which the chest is cracked open to remove the unhealthy valve, TAVR involves threading a catheter tipped with a replacement valve through a blood vessel to the heart. Doctors then implant the new valve. The old valve remains but is pushed aside, and the new one takes over its work. With this less invasive valve procedure, people can get out of the hospital within two or three days and get back to daily activities much sooner than with open-heart surgery, which typically has a six-week recovery time. TAVR has been approved by the Food and Drug Administration for people who cannot have open-heart surgery or for whom it would be risky. These include the elderly and frail and people with complications such as kidney and lung disease. But TAVR use has expanded among younger, and less sick, patients in recent years. Within the next year, the FDA is likely to approve the procedure for all patients needing a new aortic valve, industry analysts say. TAVR does carry risks, including stroke. Patients may also need a pacemaker after the procedure to regulate heart rhythm. The large majority of patients getting TAVR are 65 and over. The importance of Medicare’s blessing goes beyond its payments, since private insurers typically follow Medicare standards. Physicians seeking to expand use of TAVR point out that Medicare has no volume requirements for other major cardiac procedures. The two largest TAVR medical device companies are divided on the issue. Edwards Lifesciences Corp. of Irvine, Calif., supports eliminating the minimum-patient requirements, while Minneapolis-based Medtronic favors keeping the status quo. The Advanced Medical Technology Association, or AdvaMed, an industry trade group, also supports the change.About 50,000 patients are expected to have TAVR this year, and those numbers are forecast to double by 2020, according to American College of Cardiology and other major heart groups.When Michael Vigil, 50, needed TAVR in May, he drove more than three hours from his home in eastern Wyoming to a hospital in Denver. Before the procedure, the oil-drilling contractor was constantly tired and out of breath — even after mundane chores at home. Vigil’s aortic valve had been damaged from radiation treatments for non-Hodgkin lymphoma decades before. Vigil was sent home a day after the TAVR procedure. He was back at work the following week. He said he felt more energized almost immediately after having the procedure.”It’s worked so well my wife wishes they dialed it back a little,” Vigil said.Donnette Smith, president of the patient advocacy group Mended Hearts, said many patients don’t have good access to the procedure. “Patients do not know of this option unless they walk through the right door of the right hospital,” said Smith of Huntsville, Ala. She had heart valve surgery in 1988.Mended Heart receives funding from device makers.’Experience matters’To gain Medicare approval for TAVR programs, hospitals have to perform annually 50 open-heart valve repairs, 400 angioplasties and 1,000 cardiac catheterizations — a procedure in which medical teams use skills similar to those needed for TAVR. Doctors at larger hospitals say procedure volume is a good predictor for success. The American College of Cardiology and the Society of Thoracic Surgeons recommend hospitals be able to do at least 50 TAVRs each year within two years of startup. More than three-quarters of the 582 hospitals authorized by Medicare for TAVR meet that standard. “Whether it’s playing the violin or performing heart surgery, experience matters,” said Dr. Thoralf Sundt, chief of cardiac surgery at Massachusetts General Hospital. Dr. Ashish Pershad, an interventional cardiologist who performs TAVR at Banner Medical Center in Phoenix, agreed that there are access issues. But he said it’s not because of a lack of programs. Rather, he said, surgeons too often don’t refer patients for it because they make more money from doing the open-heart surgical valve replacement. “Patients are missing out on this procedure because they are not being referred, and primary care doctors lack knowledge about it,” he said.Expanding treatment optionsDoctors seeking a Medicare rule to widen access say there is little evidence hospitals that perform more TAVRs have lower mortality rates. As long as they can show low mortality and complications, they believe their hospitals should be able to offer the service. “Our intention is not to lower the quality of outcomes by expanding to ‘low volume’ centers; but to provide excellent care to a larger population of patients,” Felger and his colleagues at Shannon Medical Center in San Angelo, Texas, wrote to the CMS advisory group. Last year, Felger said, he sent a dozen patients to hospitals in Austin or Dallas for TAVR, while eight other patients opted for the open-heart surgery. “I have patients tell me they would rather have the surgical procedure at their local hospital than traveling to another city,” he said. “They tell me ‘Let’s do this; if I die, I die.’ “Kaiser Health News is a nonprofit news service covering health issues. It is an editorially independent program of the Kaiser Family Foundation that is not affiliated with Kaiser Permanente. Copyright 2018 Kaiser Health News. To see more, visit Kaiser Health News.last_img read more

A pioneering project to set up a usercontrolled c

first_imgA pioneering project to set up a user-controlled cooperative should boost the number of disabled people in Wales who use direct payments to fund their own support.The Citizen Directed Co-operatives Cymru (CDCC) project will support disabled people to develop a co-operative to manage their direct payments, allowing them to pool their support funding and giving them more “choice, voice and control”.The project, which has secured £500,000 funding for the next three years from the Big Lottery Fund’s BIG Innovation fund, was launched in Cardiff this week by Disability Wales and the Wales Co-operative Centre (WCC).The funding will allow Disability Wales and WCC to develop a single co-operative – set to be the first user-controlled co-operative in the UK to support disabled people with managing their direct payments – but they are hoping other such organisations will follow in its wake.Direct payments allow disabled people to take their council-funded social care packages as cash payments, giving them more flexibility and allowing them the option of recruiting their own personal assistants.The co-operative model is different to a traditional centre for independent living because it is owned by its members, who all have a say in how it is run.Rhian Davies, chief executive of Disability Wales – the national organisation of disabled people’s organisations – said: “We are hoping it will perhaps open up direct payments to a wider range of people who might currently be put off because they do not want the responsibility of employing a PA [personal assistant].”Although members will still be in control of their support, the co-operative will employ the PAs.The new organisation will also offer other options, such as members being able to pool their direct payments to fund group activities, such as drama sessions or watching a football match, or even setting up a social enterprise.Davies said: “We are hoping that this model opens up a host of opportunities that can support people in whatever independence means to them.“For some people it is about personal support, but for others it is about supporting personal interaction.”The new co-operative will also provide users of direct payments with a collective voice.Davies said the cooperative project was seen as a “companion” scheme to its Enabling Wales project, which is developing two new centres for independent living as social enterprises.Davies said that CDCC would “reignite the debate surrounding direct payments and will support and enable greater choice, voice and control for disabled people across Wales”. Although they were introduced in Wales in 1996, only just over 4,000 people are currently receiving their support through direct payments, out of about 95,500 adults (in 2012-13) receiving community-based services.Davies said the project had “emerged at the right time”, with the emphasis in the new Social Services and Well-being (Wales) Act 2014 – which comes into force in April 2016 – on finding more effective ways to support people, and on a “choice and control” agenda.The act has introduced a duty on local authorities to promote the development of co-operatives, social enterprises, user-led services and the third sector.Trevor Palmer, a Disability Wales board member, added: “As a direct payment recipient, it is such positive news to hear that the CDCC project is being delivered in Wales.“This project will create real opportunities for disabled people to live a more independent life.”The CDCC project has also secured international attention, and among those to offer their backing at the launch was Dr Adolf Ratzka, one of the most influential figures in the European independent living movement, who contributed to the research that led to the funding being awarded.Ratzka (pictured, at this week’s event) is the founder and director of Sweden’s Independent Living Institute, the founding chair of the European Network on Independent Living, and the founder and chair of the Stockholm Cooperative for Independent Living.Professor Mark Drakeford, the Welsh health and social services minister, who attended the launch, said: “A co-operative model for direct payments offers people a real opportunity to make decisions about how they want to lead their lives – independently and in control – as fully participating citizens.“It’s about supporting people to support themselves.“It is through such collaboration and delivering practical leadership and action that we will achieve our vision of a greater voice and control for citizens and their right to live independently in the community.“Co-operatives support positive social change and innovation. They are rooted in local communities.“Any investment stays in the community and is recycled for wider economic and social benefits.”The BIG Innovation fund supports projects that test “new ways of tackling emerging and existing social problems”.Picture by Natasha Hirstlast_img read more

Airbnb Hires ExUS Attorney General to Help Shape Policy

first_img 2 min read Image credit: John MacDougall | Getty Images July 21, 2016 –shares Airbnb Hires Ex-U.S. Attorney General to Help Shape Policy Airbnb said on Wednesday it hired former U.S. Attorney General Eric Holder to help craft its anti-discrimination policy to combat discrimination occurring on the home-sharing company’s platform.Airbnb, which allows private homeowners, or “hosts,” on the site to rent apartments and houses on a short-term basis, has received complaints of discrimination based on race, gender and sexual orientation.”While we have a policy that prohibits discrimination, we want this policy to be stronger,” Airbnb Chief Executive Brian Chesky said in a blog post announcing the hiring of Holder.Holder, the first African American to hold the position of U.S. Attorney General, will be working with John Relman, a civil rights attorney and authority “on fair housing and public accommodation issues,” Chesky said.In June, Holder wrote to lawmakers on behalf of ride-hailing service Uber to argue against the use of fingerprint-based background checks as they consider how to regulate ride-hailing service drivers.Airbnb has said that discrimination occurring on its platform is the biggest challenge facing the company. Last month, the hashtag #AirbnbWhileBlack trended heavily on Twitter in the United States, serving as a forum for black travelers to share experiences of racial discrimination from white Airbnb hosts. Add to Queue This story originally appeared on Reuterscenter_img Airbnb Reuters Free Webinar | July 31: Secrets to Running a Successful Family Business Next Article Learn how to successfully navigate family business dynamics and build businesses that excel. Register Now »last_img read more

Wheres Our Data IDC Executive Brief – Data Control is Crucial for

first_imgData centres are one of the foundations for successful digital transformation, and advanced levels of digitisation place the highest demands on safe and secure data housing. The right data centre is a key enabler of successful digitisation in which business processes are data driven, and where the production, computing and use of data occurs seamlessly and immediately.Marketing Technology News: 3CLogic Announces Microsoft AppSource Certification for Microsoft Dynamics CRMIDC Predicts that:During 2020 a majority of Nordic enterprises will have initiated projects to identify in which geography and in which data centre their critical data resides.Security breaches in 2019 will cause substantial brand value damage to more than 10 Nordic publicly listed companies, resulting in penalties and loss of revenue in excess of €1 billion.The energy discussion will move to the top of the agenda, as big new data centres or hyperscalers are built in the Nordics and the public realise how much energy a data centre requires.Significant buildout in the Nordics beyond 2020 as data centres need to be located closer to users to reduce latency in data traffic as cloud transformation and IoT progress.In 2019, 80% of enterprises’ new digital services will need to be housed in dedicated cloud or colocation facilities.Marketing Technology News: HipChat Founders Launch Swoot, a Social Podcast App 5 questions that every successful CIO and CEO should be able to answer:Where is our data located?                                                How is our data protected?                                                What is our digital environmental footprint?                                              What is the track record on downtime and latency in our data delivery?                                              Are we scaling up digital transformation and innovation, or spending the money on inhouse data centres and infrastructure? Data control and the housing of data are both critically important in the digital transformation economy. However, 60% of Nordic decision makers cannot say for sure where or even in which country their data resides. DigiPlex and IDC Nordic are, in this unique Executive Brief, addressing this critical knowledge gap and answering five questions to help businesses stay ahead in the digital transformation race.65% of European CEOs are under digital pressureThe comprehensive Executive Brief from IDC Nordic, in collaboration with DigiPlex, confirms that the digital transformation has implications for all organisations. Products, services and markets are transforming, and according to IDC, 65% of European CEOs are under pressure to deliver a successful digital transformation strategy to become a truly digital enterprise and to comply with local legislation. Digital infrastructure, including the housing of data, is a critical component of this pressure.“To be a successful digital player you need to know where and how your data is stored, in order to control your assets, comply with legislation and protect your brand. We are seeing increased concern over the digital environmental footprint, as well as physical protection as part of GDPR compliance and connected to risks like extreme weather or cyberattacks. These are only two of multiple key data centre factors businesses need to take into account”, says Gisle M. Eckhoff, CEO DigiPlex.Marketing Technology News: Reviving Retail with AI: 5 Benefits of Adopting AI in Retail OperationsAre you trapped in a digital deadlock?At the same time, 55% of Nordic businesses, like most other organisations all over the world, are trapped in what could be called `digital deadlock’. The challenge for these businesses is to make the leap to become a digital transformer, by starting to employ digital solutions to optimise and organise the business. This is something that requires a robust digital infrastructure.“Data centres are a growing business concern and the process of preparing the five questions has given me new insights into the important role of the data centre in digital transformation. Most importantly among these are, the issue of energy efficiency, how data centre service providers address power consumption, and the growing role of latency in digital. Location of data centres is on the agenda in the data driven economy”, says Jan Horsager, Research Director IDC Nordic. Data ControlDigiPlexDigital TransformationGisle M. EckhoffIDCMarketing Technology NewsNews Previous ArticlePrimis Awarded Recertification of TAG Certified Against Fraud Seal by Trustworthy Accountability GroupNext ArticleMarTech Interview with Henry Schuck, Founder and CEO, DiscoverOrg Where’s Our Data? IDC Executive Brief – Data Control is Crucial for Success in Digital Transformation MTS Staff WriterApril 23, 2019, 10:02 pmApril 23, 2019 last_img

MJ2 Launches New Branded Video Testimonial Tool

first_imgMJ2 Launches New Branded Video Testimonial Tool PRNewswireApril 25, 2019, 4:19 pmApril 25, 2019 Bounce Makes Video Marketing Easy for Companies, Brands and CustomersHarness the power of branded video testimonial content with Bounce, a one-stop video marketing tool by MJ2 Marketing. Once considered to be a small piece of a company’s overall marketing strategy, a video revolution has made it a necessary component of a brand’s outreach, ad campaigns and, particularly, social strategy.Bounce provides a simple, quick and cost-effective way for companies to drive social shares, increase visibility, build trust with an audience and convert customers. MJ2 Marketing, a digital marketing company based in Dublin, launched Bounce this month. The video marketing tool is an exclusive offering in the Columbus market.“Staying current with marketing trends is important to us, and video content is the next necessity for all companies and brands,” says Megan James, president of MJ2 Marketing. “There’s nothing more valuable than real people sharing their stories about how your product or service makes their lives better.”Marketing Technology News: Blueshift Raises $15 Million from Softbank to Put AI in Hands of Every MarketerBounce makes it easy for companies to create branded video testimonials in just seconds. Using the service, companies can “bounce” an invitation to record a video testimonial into a customer’s email inbox directly after a service or sale. Using their computer, tablet or mobile device, the customer can record a quick video sharing their experience with the company.  For the customer, it’s as easy as taking a selfie and hitting send. Bounce automatically adds the company’s branding, music and a call to action to the video, and it’s ready to share.MJ2 offers various Bounce packages. With a Get Started package, companies can open a Bounce account for $100 per month, and purchase credits to cover a per-video cost of $75. Companies only pay for approved videos. A free trial of Bounce is available.Marketing Technology News: Fred Santarpia, Former Chief Digital Officer at Condé Nast Inc., Named US Chief Digital Officer of the Year 2018 by CDO ClubWith a Full Service package MJ2 can implement and run the Bounce program for local companies, helping to integrate video graphics and motion into the marketing strategy and curating the video asset on social media networks and email. Contact MJ2 for pricing details.MJ2 is a full digital marketing agency with a video marketing division and a video production team. The agency uses cutting-edge technology and platforms to tell a brand’s story, offering everything from preproduction to editing services.Marketing Technology News: Aqqaint Brings Trust and Transparency to Peer-to-Peer Exchange With New Mobile App Marketing TechnologyMegan JamesMJ2 MarketingNewsvideo contentvideo marketing toolvideo testimonial content Previous ArticleIZEA Announces IZEAx 3.0 Unity SuiteNext ArticleVerblio Acquires Automagical Launches New Service to Affordably and Easily Add Video to Any Post or Storylast_img read more

Exploring novel strategies to heal damage after a heart attack

first_img Source:https://www.northwestern.edu/ Reviewed by James Ives, M.Psych. (Editor)Apr 24 2019For people who survive a heart attack, the days immediately following the event are critical for their longevity and long-term healing of the heart’s tissue. Now researchers at Northwestern University and University of California, San Diego (UC San Diego) have designed a minimally invasive platform to deliver a nanomaterial that turns the body’s inflammatory response into a signal to heal rather than a means of scarring following a heart attack.Tissue engineering strategies to replace or supplement the extracellular matrix that degrades following a heart attack are not new, but most promising hydrogels cannot be delivered to the heart using minimally invasive catheter delivery because they clog the tube. The Northwestern-UC San Diego team has demonstrated a novel way to deliver a bioactivated, biodegradable, regenerative substance through a noninvasive catheter without clogging.The research, which was conducted in vivo in a rat model, was published recently in the journal Nature Communications. Northwestern’s Nathan C. Gianneschi and UC San Diego’s Karen Christman are the co-principal investigators.”This research centered on building a dynamic platform, and the beauty is that this delivery system now can be modified to use different chemistries or therapeutics,” Gianneschi said.Gianneschi is the Jacob and Rosaline Cohn Professor in the department of chemistry in the Weinberg College of Arts and Sciences and in the departments of materials science and engineering and of biomedical engineering in the McCormick School of Engineering.When a person has a heart attack, the extracellular matrix is stripped away and scar tissue forms in its place, decreasing the heart’s functionality. Because of this, most heart attack survivors have some degree of heart disease, the leading cause of death in America.”We sought to create a peptide-based approach because the compounds form nanofibers that look and mechanically act very similar to native extracellular matrix. The compounds also are biodegradable and biocompatible,” said first author Andrea Carlini. She is now a postdoctoral fellow in the lab of John Rogers, in Northwestern’s department of materials science and engineering.”Most preclinical strategies have relied on direct injections into the heart, but because this is not a feasible option for humans, we sought to develop a platform that could be delivered via intracoronary or transendocardial catheter,” said Carlini, who was a graduate student in Gianneschi’s lab when the study was conducted.Peptides are short chains of amino acids instrumental for healing. The team’s approach relies on a catheter to deliver self-assembling peptides — and eventually a therapeutic — to the heart following myocardial infarction, or heart attack.”What we’ve created is a targeting-and-response type of material,” said Gianneschi, associate director of Northwestern’s International Institute of Nanotechnology and a member of the Simpson Querrey Institute.Related StoriesTeam approach to care increases likelihood of surviving refractory cardiogenic shockRNA-binding protein SRSF3 appears to be key factor for proper heart contraction, survivalWeightlifting is better for the heart than cardio”We inject a self-assembling peptide solution that seeks out a target — the heart’s damaged extracellular matrix — and the solution is then activated by the inflammatory environment itself and gels,” he said. “The key is to have the material create a self-assembling framework, which mimics the natural scaffold that holds cells and tissues together.”The team’s preclinical research was conducted in rats and segmented into two proof-of-concept tests. The first test established that the material could be fed through a catheter without clogging and without interacting with human blood. The second determined whether the self-assembling peptides could find their way to the damaged tissue, bypassing healthy heart tissue. Researchers created and attached a fluorescent tag to the self-assembling peptides and then imaged the heart to see where the peptides eventually settled.”In previous work with responsive nanoparticles, we produced speckled fluorescence in the heart attack region, but in this case, we were able to see large continuous hydrogel assemblies throughout the tissue,” Carlini said.Researchers now know that when they remove the florescent tag and replace it with a therapeutic, the self-assembling peptides will locate to the affected area of the heart. One hurdle is that catheter delivery in a rodent model is far more complicated — because of the animal’s much smaller body — than the same procedure in a human. This is one area where Christman’s lab at UC San Diego has deep knowledge.If the research team can prove their approach to be efficacious, then there is “a fairly clear path” in terms of progressing toward a clinical trial, Gianneschi said. The process, however, would take several years.”We started working on this chemistry in 2012, and it took immense effort to produce a modular and synthetically simple platform that would reliably gel in response to the inflammatory environment,” Carlini said. “A major breakthrough occurred when we developed sterically constrained cyclic peptides, which flow freely during delivery and then rapidly assemble into hydrogels when they come in contact with disease-associated enzymes.”By programming in a spring-like switch, Carlini was able to unfurl these naturally circular compounds to create a flat substance with much more surface area and greater stickiness. The process creates conditions for the peptides to better self-assemble, or stack, atop one another and form the scaffold that so closely resembles the native extracellular matrix.Having demonstrated the platform’s ability to activate in the presence of specific disease-associated enzymes, Gianneschi’s lab also has validated analogous approaches in peripheral artery disease and in metastatic cancer, each of which produce similar chemical and biological inflammatory responses.last_img read more

Defence establishments in Telangana denied water NITI Aayog member Saraswat

first_imgCOMMENTS Published on Telangana V.K. Saraswat, member, NITI Aayog — File picture   –  H_S_MANJUNATH DRDO March 20, 2019 SHARE SHARE EMAILcenter_img COMMENT Major defence establishments in Telangana have been denied water, according to V. K. Saraswat, Member, NITI Aayog.He was speaking at the inaugural session of the CII Telangana annual meeting and conference on Telangana 2.O: The Growth Story Continues, held here on Wednesday.”BDL and Ordanance Factory in Medak have been denied water supply. The state should focus on water,” Saraswat, who was a former secretary of the Defence Reserch and Development Organisation, said. “Telangana is going to face a major water problem in the next 25 years,” he said.Waste water recycling and water harvesting should be taken up in a big way as the water problem is going to become serious after 2035, he added.The present state government, which has got a massive mandate, should continue welfare and development schemes, but also evaluate their impact.The focus should also be on education, smart education, smart cities and e-waste, among others, he said.Sustainable Development Goals (SDGs) should guide Telangana 2.0’s development, he said, adding: “The Telangana foundation learning index is not so good and focus should be given on school education,” the NITI Aayog member said.Referring to growth in Telangana, Saraswat said in the last five years, many schemes such as Mission Kakatiya and Rhythu Bandhu did help the state achieve growth in diverse areas.Jayesh Ranjan, Pricipal Secretary, Industries & Commerce, Telangana, said entrepreneurship was catching on among young students and the CII and Telangana government could collaborate in its promotion and innovation. defence SHARE defence contractlast_img read more

21 States have framed rules to curb illegal mining Minister

first_img Twenty one States, including mineral-rich Jharkhand and West Bengal, have framed rules to check illegal mining, Parliament was informed on Wednesday. “As per information provided by the Indian Bureau of Mines, 21 State governments… have framed rules to curb illegal mining under Section 23C of the MMDR Act, 1957,” Coal and Mines Minister Pralhad Joshi said in a written reply in the Lok Sabha. State governments, he said, are empowered to make rules for the prevention of illegal mining, transportation and storage of major and minor minerals, the Minister said. In fiscal 2018-19, there were 1.1 lakh cases of illegal mining for both major and minor minerals. SHARE SHARE EMAIL Coal and Mines Minister Pralhad Joshi economic offence mining and quarrying July 10, 2019center_img COMMENTS SHARE Published on COMMENTlast_img read more