Finding our genomic clockwork

first_img In pursuit of healthy aging Critical step found in DNA repair, cellular aging Experiments in mice suggest way to thwart DNA damage from aging, radiation Related Harvard study shows how intermittent fasting and manipulating mitochondrial networks may increase lifespan For this new study, the researchers looked at the rDNA, the most active segment of the genome and one that has also been mechanistically linked to aging in a number of previous studies. Lemos and lead author Meng Wang, a research fellow in the Department of Environmental Health, hypothesized that the rDNA is a “smoking gun” in the genomic control of aging, and might harbor a previously unrecognized clock. To test the idea, they examined epigenetic chemical alterations (also known as DNA methylation) in CpG sites, where a cytosine nucleotide is followed by a guanine nucleotide. The study homed in on the rDNA, a small (13-kilobase) but essential and highly active segment of the genome, as a novel marker of age.Analysis of genome-wide data sets from mice, dogs, and humans indicated that the hypothesis had merit: Numerous CpGs in the rDNA exhibited signs of increased methylation — a result of aging. To further test the clock, they studied data from 14-week-old mice that responded to calorie restriction, a known intervention that promotes longevity. The mice that were placed on a calorie-restricted regimen showed significant reductions in rDNA methylation at CpG sites compared with mice that did not have their diet restricted. Moreover, calorie-restricted mice showed rDNA age that was younger than their chronological age.The researchers were surprised that assessing methylation in a small segment of the mammalian genome yielded clocks as accurate as clocks built from hundreds of thousands of sites along the genome. They noted that their approach could prove faster and more cost-effective at determining biological and chronological age than current methods of surveying the dispersed sites in the genome. The findings underscore the fundamental role of rDNA in aging and highlight its potential as a widely applicable predictor of age that can be calibrated for all mammalian species.Importantly, the clocks respond to interventions, which could allow scientists to study how biological age responds to environmental exposures and lifestyle choices. Ascertaining an accurate biological age can indicate of how much better or worse an individual is doing relative to the general population, and could potentially help monitor whether that person is at heightened risk of death or a given disease. Work in Lemos’ lab has been partially supported by the National Institute of Environmental Health Sciences, the Lawrence Ellison Medical Foundation, and the Richard and Susan Smith Family Foundation, though the authors received no specific funding for this work.  A newly discovered ribosomal DNA (rDNA) clock can be used to accurately determine an individual’s chronological and biological age, according to research led by Harvard T.H. Chan School of Public Health. The ribosomal clock is a novel biomarker of aging based on the rDNA, a segment of the genome that previously has been mechanistically linked to aging. It has potentially wide applications, including measuring how exposures to certain pollutants or dietary interventions accelerate or slow aging in a diversity of species, including mice and humans.“We have hopes that the ribosomal clock will provide new insights into the impact of the environment and personal choices on long-term health,” said senior author Bernardo Lemos, associate professor of environmental epigenetics. “Determining biological age is a central step to understanding fundamental aspects of aging as well as developing tools to inform personal and public health choices.”The study was published online today in Genome Research.Aging is exhibited by organisms as diverse as yeast, worms, flies, mice, and humans. Age is also the major risk factor for a plethora of diseases, including neurological diseases, cardiovascular diseases, and cancer. There are two types of age: chronological age, or the number of years a person or animal has lived, and biological age, which accounts for lifestyle factors that can shorten or extend lifespan, including diet, exercise, and environmental exposures. Overall, biological age has been shown to be a better predictor of all-cause mortality and disease onset than chronological age. Overall, biological age has been shown to be a better predictor of all-cause mortality and disease onset than chronological age.last_img read more

How To Repair Your Garbage Disposal With Alure Home Improvements

first_imgSign up for our COVID-19 newsletter to stay up-to-date on the latest coronavirus news throughout New York Sponsored Content Brought To You By Alure Home ImprovementsSometimes your garbage disposal unit can really get you into a jam. Maybe a bone leftover from a Porterhouse steak manages to slip past the dirty plates piled in the sink and goes down the drain before it’s too late—we hate when that happens! But sometimes it’s something more precious, like a wedding ring, let’s say, that slips off your finger while you’re doing the dishes and suddenly disappears in the suds. Before you know it, it winds up in the disposer by mistake. Hopefully, you spot it before the blades find it in the grinding chamber.Accidents do happen, but that doesn’t mean you have to despair over your garbage disposal.In this recent installment of Alure Home Improvement’s “60-Second Fix,” Doug Cornwell, chief operating officer of Alure Home Improvements, gets to the bottom of the garbage disposal mechanism to reveal what you need to know to stay on top of this convenient kitchen appliance.“What happens when it jams is that it shuts the power off,” says Cornwell. “Now you’ve got a situation where the disposal doesn’t work.”As if that’s not enough, sometimes water may start surging back up into the kitchen sink with the possibility of overflowing and spilling onto the floor. It can be a nerve-wracking, frustrating predicament that every home owner dreads. Fortunately, thanks to Alure’s Doug Cornwell, the solution doesn’t mean you have to ditch the kitchen sink, throw the baby out with the bathwater, so to speak, or go down the drain with your hopes and dreams of having a good day.The first thing you’ll need is the special crank that came with the disposer when you bought it. Moral of the story: Don’t throw that tool away! Second lesson: If you kept it, remember where you put it. Third lesson: If you can’t find it, a suitable Allen wrench will do.If you’re learning these lessons too late, that’s okay. But you’ll have to make sure that a new wrench you buy from your favorite hardware store will properly fit the screw at the bottom of the garbage disposal assembly. The slot is right in the middle of the bottom, the center of the axis. Insert the wrench there and start to turn it; if it’s in the slot, the crank will move the gears and the blades inside the disposer chamber. If the wrench jams in one direction, turn it in the opposite direction. Try to rotate it completely at least two full circles. Then try a full rotation in the other direction.“Once it’s moving free, you’ve taken care of the jam,” says Cornwell.There’s a mini-circuit breaker that may pop out when the electrical system is overloaded. You’ll see that it’s a little red button on the disposal assembly. Just push the button back in and the electricity will come back on and the disposal should be back in business.That’s not too hard to get out of that jam, is it?Click here to learn more about Alure Home ImprovementsOne thing you never want to do is reach into the disposer with your fingers. Try tongs first. And remember the most important advice: For recovery missions, always make sure the garbage disposal’s power is shut off! As Cornwell says, when it’s jammed, the power shuts off automatically, but you still need to be cautious. If there’s a little object—though no less valuable to you—like a wedding ring involved, the grinding mechanism may still be able to function, so it’s always best to take precaution. And that goes for any home repair you decide to take on yourself.last_img read more

Zlarin is the first Croatian island without disposable plastic

first_imgWithin Adriatic Plastic Challenge (APC), an initiative organized by Terra Hub, selected the best innovative solutions that will help stop the further influx of plastic waste into the Adriatic Sea.In a fierce anti-plastic fight, the team “Zlarin – an island without plastic” whose vision is to make Zlarin the first Croatian island without disposable plastic won. Originally from Zlarin, Ana Nataša and Ivana have developed a model that will stop the flow of disposable plastic to the island in the next year.”Zlarin is an island with about two hundred inhabitants, which makes it an ideal place to try this experiment. We only have one supermarket and a few cafes and restaurants which significantly reduces the number of people who need to support our idea. The local community gives us great support and we can’t wait for Zlarin to come to life without plastic”Winning team member Ana Robb told Morski.hrPlastic bags will be replaced by paper and canvas ones, straws will be thrown out, and plastic cups and cutlery will also be replaced with more environmentally friendly solutions. The project is supported by the local population and the tourist board of the island of Zlarin.“We are looking for innovative solutions to the problem of accumulating plastic waste in the sea. Solutions that will work better and faster than normal. Or which will accelerate the emergence of completely new models. Or that will dramatically change the way we do or imagine something possible now. ” point out the organizers of the APC.During the two-day bootcamp, the selected teams, with the help of a mentor, turned the project solutions into business models using design thinking and lean start-up methodologies, and presented their ideas to an expert jury.The implications of this great idea, in addition to environmental awareness and sustainability, can certainly be transferred to tourism, and through a specific ecological tourism product to turn Zlarin into a destination that offers minimal or no impact on the environment with maximum use of local food and resources. If we look further, Zlarin can become the best ambassador of sustainable tourism, because it will become the first island without plastic. And not only through tourism but also through the implementation of all other industries that nurture sustainability and ecology, to the development of the city and the whole community, etc.… Opportunity for development, which was created from a small but powerful idea and vision of development.last_img read more

Industry Minister calls for tax waiver for new cars to boost sales

first_imgIndustry Minister Agus Gumiwang Kartasasmita has urged Finance Minister Sri Mulyani Indrawati to temporarily exempt vehicle tax (PKB) for new cars until December in a bid to boost car sales amid COVID-19 pressures.According to Government Regulation No. 73/2019, new passenger car purchases are subject to a luxury tax (PPnBM) of between 15 and 70 percent, depending on the vehicle’s maximum passenger capacity and engine cylinder.“If consumer purchasing power can be boosted by the tax relaxation, then we will apply it. Hopefully, it can help the automotive manufacturing industry’s growth,” Agus said in a press release on Monday. Agus said there was potential for positive developments in the automotive industry’s performance in the second half of the year.“That’s why we hope the tax waive can soon be applied to boost the nation’s automotive industry and economic recovery,” he said.Carmarker PT Toyota Motor Manufacturing Indonesia’s external relation director, Bob Azam, welcomed the minister’s initiative, saying the tax deduction would help increase car sales.“We hope there can be a tax deduction to stimulate spending without hurting the central government’s revenue. Maybe we could make the deduction from the local administration’s tax revenue,” he said in a statement.Read also: Light at end of tunnel for auto industry as June car sales rebound: ExpertsTopics : The pandemic has affected car sales this year as consumer purchasing power dwindles and large scale social restrictions (PSBB) force showrooms to close temporarily.While there were signs of a sales rebound in July with around 25,200 cars sold, which is more than double the June sales of 12,600, the figure is still far lower than the 89,200 cars sold in July 2019, according to Association of Indonesian Automotive Manufacturers (Gaikindo) data. From the total July 2020 sales, passenger cars make up more than half at 15,200 units.Between January and July this year, the country’s car sales were down by 50 percent year-on-year (yoy) to around 286,200 from 571,300 on the same period last year, Gaikindo data shows.Gaikindo projected earlier that this year’s car wholesales would only reach 600,000 units, a 42 percent plunge from last year.last_img read more

Domenico Vacchiano joins Magellan Robotech

first_img Share StumbleUpon Magellan Robotech, a subsidiary of Stanleybet Group, has strengthened its senior leadership team after naming Domenico Vacchiano as its new Head of Technology.Prior to joining Magellan Robotech, Vacchiano served as tech leader and a member of the tech management team at Gaming Innovation Group (GiG). He has also served as a member of board of directors and CTO at WeAreCasino.Earlier in his career, Vacchiano also served the UK branch of Derivco, where he worked in the mobile native team contributing with the Betway iOS app development.Commenting on his new appointment, Vacchiano said: “Magellan Robotech is a company that is built on market-changing innovations, with an exciting environment and an engaging cutting-edge technology culture, where I’m thrilled starting to contribute with my extensive technology and iGaming experience.”Pierluigi Chiusolo, Executive Director of the Stanleybet Group, welcomed Vacchiano by saying: “I’m proud that Domenico has decided to join our team and I am looking forward to seeing how much our development team will benefit from his experience and technical competence.“Domenico will work very close to myself and the Head of the online products to build the next generation platform and make available to the industry one of the most appealing and complete turnkey solutions.” Related Articles B2B plans on hold for Betsson despite strong Q1 opening April 23, 2020 GiG launches WSN Podcast hosted by Bill Krackomberger  June 18, 2020 GiG lauds its ‘B2B makeover’ delivering Q2 growth August 11, 2020 Share Submitlast_img read more